Replacement Fluids: Albumin and Plasma
What replaces the plasma that is removed
Understanding replacement fluids
When plasma is removed during TPE, it has to be replaced. Common replacement fluids include albumin and, in some cases, donor plasma.
ASFA describes 5% human albumin as the most commonly used replacement fluid, with donor plasma used in some cases. Johns Hopkins patient education similarly lists albumin, saline, or fresh frozen plasma as common replacement fluids.
Albumin
Albumin is a protein solution. It is commonly used as the replacement fluid in TPE.
Plasma
In some situations, donor plasma is used instead. Plasma exchange patient guidance from ACR notes that the replacement fluid may come from donors.
Why this matters to patients
You do not need to become an expert in replacement fluids, but you should know what you are receiving and why.
• What replacement fluid will you use?
• Why is it the best choice for my condition?
• Does this change anything I should watch for after treatment?
• Should I tell you about any preference to avoid blood products?
ACR specifically advises telling your medical team if you avoid blood products.